Sensitivity of technetium-99m-d,1-HMPAO to radiolysis in aqueous solutions.
نویسندگان
چکیده
The sensitivity of technetium-99m- (99mTc) d,l-HMPAO to radiolytically induced dissociation in aqueous solutions was investigated. It was found that cobalt-60 (60Co) gamma irradiation of solutions containing 99mTc-d,l-HMPAO with only 1600 cGy reduced the lipophilic chelates' radiochemical purity (RCP) to 50%-60%. The radiolytic sensitivity of 99mTc-meso-HMPAO is significantly lower. The results indicate that radiolytically produced intermediates limit the in vitro stability of 99mTc-d,l-HMPAO.
منابع مشابه
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Received 2/13/2001; revised 8/10/2001; accepted 11/1/2001. For correspondence or reprints contact: Jem-Mau Lo, Department of Nuclear Science, National Tsing Hua University, 101 Section 2, Kuang-Fu Road, Hsinchu 300, Taiwan. Tel: (886)3-5727308, Fax: (886)3-5718649, E-mail: [email protected] The intracellular distributions of Tc-d,l-HMPAO, Tcmeso-HMPAO and Tc-PnAO in rat brains were explored i...
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ورودعنوان ژورنال:
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine
دوره 32 1 شماره
صفحات -
تاریخ انتشار 1991